Potential Man United XI: De Gea; Valencia, Lindelof, Smalling, Blind; Matic, Herrera, Pogba, Mkhitaryan; Martial, Lukaku
Having enjoyed quite a successful pre-season Manchester United will look to hit the ground running in 2017-18 by winning some silverware in Macedonia.
The Red Devils struggled to assert themselves domestically last season, finishing a dismal sixth in the Premier League, but they excelled in Europe and Mourinho has slowly but surely put his stamp on the team he inherited from Louis van Gaal in 2016.
As well as winning the Europa League, Mourinho guided United to EFL Cup glory last term and he will attempt to build on the foundations that he laid at Old Trafford during his maiden campaign at the helm.
The additions of Matic, Lindelof and Lukaku bring greater strength to all areas of the pitch and a competitive victory over the Champions League holders in Skopje would send out a real signal of intent to United's rivals ahead of the new season.
While ex-Real boss Mourinho is meeting his old employers, so too is Cristiano Ronaldo, who is hoping to feature against the Red Devils after making a return to training over the weekend.
The Portugal international played no part in the Blancos' pre-season preparations due to his involvement in the Confederations Cup and off-field distractions surrounding allegations of tax faud have intertwined with speculation that the talismanic forward is nearing an exit from the Santiago Bernabeu.
As a result, it will be interesting to see if Ronaldo is handed a starting position by Zidane, who will no doubt be keen to see his star attacker remain at the club.