Quinine ni dawa ambayo haipo salama kwa mjamzito.
Quinine has been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of teratogenicity. There are no controlled data in human pregnancy. Congenital abnormalities (including damage to the auditory and optic nerve) have been reported following the use of large doses of quinine for its abortifacient effect. Quinine is only recommended for use during pregnancy when there are no alternatives and benefit outweighs risk.
The researchers found that malaria increased the risks of miscarriage from one in five pregnancies (in women without malaria) to one in two pregnancies.
Where women were infected with malaria but had no noticeable symptoms (asymptomatic malaria), the risk of miscarriage was one in three pregnancies.
Artemisinin-based combination therapy (ACT) is recommended by the World Health Organization as the treatment for all malaria caused by the
P. falciparum species of malaria parasite –
except in the first trimester of pregnancy. This is because animal studies have indicated that the drugs can be toxic to embryos.
Yet the researchers found that after first-trimester malaria treatment, the likelihood of miscarriage was similar in women treated with
chloroquine (26%), quinine (27%), and artemisinin (31%). And there were no differences between the treatments in other outcomes such as stillbirth or low birth weight.
The researchers conclude: ‘A randomised trial of first-trimester artemisinin-based treatment is now needed to make firm recommendations on the safety of first-trimester malaria treatments with this class of antimalarial drug.'
By ‘Dr McGready.
Mpaka sasa, Quinine inaaminika kuwa ni dawa salama wakati wa ujauzito (1st trimester), kama kunadawa nyingine mbadala naomba iwekwe hapa ili sote tupate maarifa tufuatilia justification zake, badala ya kurely kwe sentensi kama "
Quinine is only recommended for use during pregnancy when there are no alternatives and benefit outweighs risk" ambazo hazitoi suluhisho
Halafu ikumbukwe Quinine inatolewa katika dose ambayo inafikia therapeutic level tu, na sio large dose za kufikia arbotifacient dose ikiwa lengo ni kutibu na si kufanya abortion