Dinos Mavropanos is still expected to be out for six to eight weeks and Emile Smith Rowe is not ready to return yet.
Bernd Leno will continue in goal for Arsenal and he will be backed up by Sokratis Papastathopoulos and new boy Luiz in central defence.
Ainsley Maitland-Niles and Nacho Monreal are expected to fill the full-back positions in a four man defence.
Who Emery will decide to play in central midfield is open to debate but Granit Xhaka and Lucas Torreira are the most likely starters.
Henrikh Mkhitaryan could start on the right with Pepe still returning to match fitness after his African Nations exploits with Ivory Coast.
Mesut Ozil and Sead Kolasinac have not travelled north because of “further security incidents”.
Two weeks ago the pair were involved in an attempted carjacking and the club have confirmed they have taken the decision not to include the duo just yet.
Striker Alexandre Lacazette is still a doubt following an ankle injury sustained in pre-season but should play some part.
Right-back Hector Bellerin is out until October, while Rob Holding is still not match fit.
Dinos Mavropanos is still expected to be out for six to eight weeks and Emile Smith Rowe is not ready to return yet.
Bernd Leno will continue in goal for Arsenal and he will be backed up by Sokratis Papastathopoulos and new boy Luiz in central defence.
Ainsley Maitland-Niles and Nacho Monreal are expected to fill the full-back positions in a four man defence.
Who Emery will decide to play in central midfield is open to debate but Granit Xhaka and Lucas Torreira are the most likely starters.
Henrikh Mkhitaryan could start on the right with Pepe still returning to match fitness after his African Nations exploits with Ivory Coast.
With Ozil missing out this weekend, 19-year-old Joe Willock may get a chance to impress in the central attacking role.
New loan signing Dani Ceballos could place that role if Emery deems him fit enough to start.
If Lacazette is passed fit as expected then he will play through the middle with Pierre-Emerick Aubameyang on the left side.
Arsenal predicted line-up vs Newcastle:
(4-2-3-1): Leno; Maitland-Niles, Luiz, Sokratis, Monreal; Xhaka, Torreira; Willock, Aubameyang, Mkhitaryan; Lacazette