Juan Mata is also a long-term absentee while Donny van de Beek also remains sidelined with an unspecified injury.
In goal, Dean Henderson will continue to deputise for David de Gea as the Spanish stopper remains in his homeland following the birth of his first child.
Victor Lindelof, who also missed the Palace draw with back trouble, has returned to the squad and is in contention for a starting place.
"I'd believe at least Victor should be fine,” Solskjaer said of the Swedish defender.
“He was on the bench. He was still feeling the effects of his back but hopefully he'll be OK.”