Hi all.
I have done some quick study to ascertain myself if kikombe cha babu works or not. Kinemo and Mercy sent us some literature to go through and by doing that, it came to my understanding that this plant contains for ingredients namely carissol, lupeol, amyrin and oleuropein.
Fortunately, structures of these compounds are known already and therefore can be subjected to modern drug discovery methods. I decided to dock all four compounds to known HIV drug targets which are reverse trancriptase, protease and intergrase.
The firsrt three compounds bound tightly to allosteric receptor of reverse transcriptase, the one utlized by nevirapine and had affinity to the receptor than nevirapine and effavirenz. oleuropein did not bind anywhere since it is water soluble.
I went further and docked all four to the protease enzyme and again the forst three bound to the enzyme in the similar pocket to those used by existing drugs with more zeal. Docking these drugs to the integrase enzyme, the first three compounds were simply outliers, which means they did not interact with the enzyme but oleuropein docked in the enzyme in the allosteric receptor.
I was amazed on the Babu's drug wonder. Having three molecules that can hit two receptors of reverse transcriptase and protease at once is a dream prospect for most scientists and the fourth complementing them by binding the integrase target in a single cup. Which means, if this plant is developed into the drug, the current HIV regimen with so many drugs will become irrelevant. I know these molecules may also hit other targets which are not yet characterized and validated.
And more, the first three compounds have a sterol nucleus and therefore, they are lipophilic.
This is very important because it enables these compounds to penetrate to the HIV hiding areas where the current drugs have no access and it can also treat CNS viral infection.
I am of course preparing a manuscript to publish my findings. I know there are people who attach Babu's cup to divine miracles which is very important. What I can also add to this is that the drugs work in a scientifically scientifically sound reasoning and while people should keep on going to loliondo, I think my friends at the Pharmacognosy departments should start something. I am ready to cooperate in case my contribution is needed.
In the mean time, I my studies on the influence of these compounds are underway and I will keep you informed.
Thanks.
Hildebert
I have done some quick study to ascertain myself if kikombe cha babu works or not. Kinemo and Mercy sent us some literature to go through and by doing that, it came to my understanding that this plant contains for ingredients namely carissol, lupeol, amyrin and oleuropein.
Fortunately, structures of these compounds are known already and therefore can be subjected to modern drug discovery methods. I decided to dock all four compounds to known HIV drug targets which are reverse trancriptase, protease and intergrase.
The firsrt three compounds bound tightly to allosteric receptor of reverse transcriptase, the one utlized by nevirapine and had affinity to the receptor than nevirapine and effavirenz. oleuropein did not bind anywhere since it is water soluble.
I went further and docked all four to the protease enzyme and again the forst three bound to the enzyme in the similar pocket to those used by existing drugs with more zeal. Docking these drugs to the integrase enzyme, the first three compounds were simply outliers, which means they did not interact with the enzyme but oleuropein docked in the enzyme in the allosteric receptor.
I was amazed on the Babu's drug wonder. Having three molecules that can hit two receptors of reverse transcriptase and protease at once is a dream prospect for most scientists and the fourth complementing them by binding the integrase target in a single cup. Which means, if this plant is developed into the drug, the current HIV regimen with so many drugs will become irrelevant. I know these molecules may also hit other targets which are not yet characterized and validated.
And more, the first three compounds have a sterol nucleus and therefore, they are lipophilic.
This is very important because it enables these compounds to penetrate to the HIV hiding areas where the current drugs have no access and it can also treat CNS viral infection.
I am of course preparing a manuscript to publish my findings. I know there are people who attach Babu's cup to divine miracles which is very important. What I can also add to this is that the drugs work in a scientifically scientifically sound reasoning and while people should keep on going to loliondo, I think my friends at the Pharmacognosy departments should start something. I am ready to cooperate in case my contribution is needed.
In the mean time, I my studies on the influence of these compounds are underway and I will keep you informed.
Thanks.
Hildebert
