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HIV antibody discovery a step toward vaccine

Discussion in 'JF Doctor' started by BAK, Jul 11, 2010.

  1. BAK

    BAK JF-Expert Member

    Jul 11, 2010
    Joined: Feb 11, 2007
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    July 9th, 2010
    11:49 AM ET

    HIV antibody discovery a step toward vaccine
    After years of disappointment, researchers have finally found a potential basis for an HIV vaccine. Scientists at the National Institute of Allergy and Infectious Diseases say they have discovered three human antibodies that neutralize more than 90 percent of the current circulating HIV-1 strains.

    "This is significant because we've now found antibodies that are good templates for HIV vaccine development," explains Peter Kwong, chief of structural biology for the institute, and co-author of the study published Thursday in the journal Science. "You can potentially inactivate the virus," he says.

    Although previous antibodies were promising, Kwong says, they often posed structural challenges that made them more difficult in terms of vaccine production. The researchers were able to narrow the data to three specific antibodies that are able to bind to a "site of vulnerability" on the HIV-1 strain, and it also helps that these antibodies appear in about 10 percent of all people currently infected with HIV.

    "With this information we know the human immune system can make the antibodies, and this suggests the capability of the human body to make them in mass."

    Dr. Anthony Fauci, who heads the NIAID, tells CNN that it’s really rare that someone would get a good immune response against the virus that causes AIDS. Researchers now have found one individual who had such an immune response. “Now that we have those antibodies, we can use them to precisely identify the virus," says Fauci. He adds this is a new concept and “the potential for a vaccine is here.”

    HIV/AIDS is the world's leading infectious killer, ccording to the World Health Organization. The disease accounted for an estimated 2 million deaths in 2008, and more than 33 million people are living with the disease worldwide.

    The researchers say the findings put them one step closer to their goal, and among their next steps are plans to make sure other people – not just those infected with HIV – can create these types of antibodies, and figure out how to derive the right inputs to be able to potentially mass produce more "broadly-neutralizing" antibodies to block nearly all HIV strains in the future.

    Post by: Sabriya Rice -CNN Medical Producer
    Filed under: AIDS
  2. Masika

    Masika JF-Expert Member

    Jul 11, 2010
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    one good step but still hard work ahead
  3. BAK

    BAK JF-Expert Member

    Jul 11, 2010
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    That is very true Mkuu, one step at a time to eliminate or reduce the negative impact of this killer disease.
  4. B

    Bawa mwamba JF-Expert Member

    Jul 12, 2010
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    Huu UGONJWA UPO KWELI? au ni kiini MACHO?????
  5. MziziMkavu

    MziziMkavu JF-Expert Member

    Jul 13, 2010
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    Dawa ya ukimwi yagunduliwa

    [​IMG]bendera ya Marekani nchi ambayo wanasayansi wake wanadaiwa kuwa wamegundua dawa ya Ukimwi

    Leon Bahati

    WANASAYANSI nchini Marekani wamegundua chembechembe za kinga ambazo zinauwezo mkubwa wa kupambana na kuua virusi vya ugonjwa wa Ukimwi ambao hadi sasa hauna chanjo wala tiba ya uhakika.

    Ugunduzi huo tayari umethibitishwa na wataalamu mbalimbali, ikiwemo Mamlaka ya Chakula na Dawa ya Marekani.

    Vyombo mbalimbali vya habari vya kimataifa vimeripoti kuhusu ugunduzi huo ambao unaelekea kutoa mapambazuko mapya kwa ugonjwa huo hatari ambao umekuwa ukiathiri nguvu kazi sehemu mbalimbali duniani, hususan nchi zinazoendelea.

    Wanasayansi hao wa Taasisi ya Magonjwa ya Kuambukiza na Mzio (Niaida) walieleza katika taarifa yao ya wiki iliyopita kuwa kwenye utafiti huo wamebaini aina mbili za chembechembe zinazoweza kumsaidia binadamu kupambana na virusi vya ukimwi.

    Mkurugenzi wa Niaida, Dk Anthony Fauci alizitaja chembechembe hizo za kinga kuwa ni VRCO1 na VRCO2 ambazo utafiti wake umeonyesha kuwa zinaweza kuua virusi vya ukimwi kwa asilimia 90.

    Kwa mujibu wa Shirika la Afya Duniani (WHO) dawa huthibitishwa pale uwezo wake wa kupambana na ugonjwa unapozidi asilimia 60.

    Dk Fauci alisema hayo ni mafanikio makubwa ya kisayansi tangu wataalamu mbalimbali duniani waanze kufanya utafiti wa namna ya kutibu ugonjwa huo.

    Alisema chembechembe hizo za kinga hizo VRCO1 na VRCO2 zinaweza kutumika katika kubaini aina mpya ya chanjo ambayo itamuwezesha binadamu kuwa na kinga dhidi ya virusi vya Ukimwi.

    Kwa namna chembechembe hizo zinavyofanya kazi, alisema, zikitumika kama chanjo, mwili wa anayechanjwa unajenga kinga ambayo inavishambulia virusi vya Ukimwi na kuviua.

    “Kwa sasa soko lina dawa za kupunguza nguvu na kasi ya virusi vya Ukimwi kuathiri chembechembe nyeupe za kujikinga na maradhi na hakuna tiba,” alisema Dk Fauci.

    “Lakini utafiti huu ni njia mpya ya kuelekea kupata ufumbuzi wa kudumu katika utaalamu wa tiba.”

    Hata hivyo, alisema utafiti huo unaweka matumaini zaidi katika kutoa chanjo ingawa baadaye utawezesha kusaidia kupatikana kwa tiba kamili.Jinsi walivyoendesha utafiti huo, Dk Faci alisema walichukua sampuli mbalimbali za damu zenye virusi vya ukimwi kutoka maeneo mbalimbali duniani.

    Katika sampuli hizo, alisema waliweza kupata aina karibu 200 za virusi vya ukimwi na walipozipambanisha na chembechembe za kinga za VRCO1 na VRCO2, virusi vilikufa bila kuathiri chembechembe nyingine za damu.
    Hali hiyo aliilezea kuwa inathibitisha kuwa VRCO1 na VRCO2 zina uwezo wa kupambana na aina zote za virusi vya ukimwi.
    Dawa ya ukimwi yagunduliwa
  6. J

    Jack Beur JF-Expert Member

    Jul 13, 2010
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    They are just playing us, they are the ones who created the dse, they are now making a lot of money by doing business in HIV /AIDS related supplies,machines and medications, it is a trap,we never get out,can you believe one CD4 count machine costs almost 100 Mil Tsh, spare the Hematology and Biochemistry machine which their prices are untouchable.
  7. Abdulhalim

    Abdulhalim JF-Expert Member

    Jul 13, 2010
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    Waandishi wa bongo bana..

    Those guys were just working on antibodies na imeonekana kuna uwezekano kwa hizo antibodies ku-multiply, hawajaanza hata kuwork kwene vaccine..
  8. Raia Fulani

    Raia Fulani JF-Expert Member

    Jul 13, 2010
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    Ni habari njema mno!