α,N,N-Trimethyltryptamine (α,N,N-TMT, α-TMT, or ATMT), also known as α-methyl-N,N-dimethyltryptamine (α-methyl-DMT or α-Me-DMT), as well as Alpha-N, is a psychedelic drug of the tryptamine family. It is similar in structure to other psychoactive tryptamines such as N,N-dimethyltryptamine (DMT) and α-methyltryptamine (αMT).
The drug has been tested in animals and compared with αMT. It was found to produce similar effects, such as hyperlocomotion and reversal of reserpine-induced behavioral depression, but with only around half the potency of αMT. α,N,N-TMT was briefly mentioned by Alexander Shulgin in his 1997 book TiHKAL (Tryptamines I Have Known and Loved), but he did not mention having tested it and did not describe its effects, dosage, or duration. In 2025, Hamilton Morris described having synthesized and assayed α,N,N-TMT. He reported that it was an active psychedelic taken orally but was much less potent than AMT.
α,N,N-TMT was encountered as a novel designer drug in Europe by 2015.
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