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Uric acid - blood

Discussion in 'JF Doctor' started by MziziMkavu, Sep 26, 2011.

  1. MziziMkavu

    MziziMkavu JF-Expert Member

    #1
    Sep 26, 2011
    Joined: Feb 3, 2009
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    Uric acid is a chemical created when the body breaks down substances called purines. Purines are found in some foods and drinks, such as liver, anchovies, mackerel, dried beans and peas, beer, and wine.

    Most uric acid dissolves in blood and travels to the kidneys, where it passes out in urine. If your body produces too much uric acid or doesn't remove enough if it, you can get sick. High levels of uric acid in the body is called hyperuricemia.
    This test checks to see how much uric acid you have in your blood.


    How the Test is Performed

    A blood sample is needed. For information on how this is done, see: Venipuncture

    How to Prepare for the Test


    You should not eat or drink anything for 4 hours before the test unless told otherwise. Your doctor may also tell you to stop taking any drugs that may affect the test results. Never stop taking any medicine without talking to your doctor.
    Drugs that can increase the level of uric acid in your body include:
    • Alcohol
    • Ascorbic acid
    • Aspirin
    • Caffeine
    • Cisplatin
    • Diazoxide
    • Diuretics
    • Epinephrine
    • Ethambutol
    • Levodopa
    • Methyldopa
    • Nicotinic acid
    • Phenothiazines
    • Theophylline
    Drugs that can decrease the level of uric acid in your body include:
    • Allopurinol
    • Azathioprine
    • Clofibrate
    • Corticosteroids
    • Estrogen
    • Febuxostat
    • Glucose
    • Guaifenesin
    • Mannitol
    • Probenecid
    • Warfarin
    Why the Test is Performed

    This test is done to see if you have high levels of uric acid in your blood. High levels of uric acid can cause goutor kidney disease.
    Your doctor may also order this test if you have had or are about to have certain types of chemotherapy. Rapid weight loss, which may occur with such treatments, can increase the amount of uric acid in your blood.

    Normal Results


    Normal values range between 3.5 and 7.2 mg/dL.
    Note: Normal values may vary slightly from laboratory to laboratory.
    What Abnormal Results Mean

    Greater-than-normal levels of uric acid (hyperuricemia) may be due to:
    Lower-than-normal levels of uric acid may be due to:
    Additional conditions under which the test may be performed:
    References

    Curhan GC, Mitch WE. Diet and kidney disease. In: Brenner BM, eds. Brenner and Rector’s The Kidney. 8th ed. Philadelphia, Pa: Saunders Elsevier; 2008:chap 53.
    Update Date: 5/30/2011

    Updated by: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

    Source: Uric acid - blood : MedlinePlus Medical Encyclopedia
     
  2. MziziMkavu

    MziziMkavu JF-Expert Member

    #2
    Sep 26, 2011
    Joined: Feb 3, 2009
    Messages: 38,548
    Likes Received: 2,809
    Trophy Points: 280
    Uric acid - urine

    Uric acid is a chemical created when the body breaks down substances called purines. Purines are found in some foods and drinks, such as liver, anchovies, mackerel, dried beans and peas, beer, and wine. Purines are also a part of normal body substances, such as DNA.

    Most uric acid dissolves in blood and travels to the kidneys, where it passes out in urine. If your body produces too much uric acid or doesn't remove enough of it, you may get sick. High levels of uric acid in the body is called hyperuricemia.
    This test checks to see how much uric acid you have in your urine.


    How the Test is Performed

    A 24-hour urine sample is needed. See: 24-hour urine collection.

    How to Prepare for the Test

    Your doctor may tell you to stop taking any drugs that may affect the test results. For example, high levels of vitamin C and dyes used during certain x-rays may cause incorrect results.
    Drugs that can interfere with test results include:
    • Alcohol
    • Allopurinol
    • Anti-inflammatory drugs (such as ibuprofen)
    • Salicylates (including aspirin)
    • Thiazide diuretics
    • Probenecid
    This list may not be all-inclusive.

    How the Test Will Feel


    The test involves only normal urination, and there is no discomfort.
    Why the Test is Performed

    This test may be done to diagnose the cause of kidney stones. It may also be used to monitor people with gout, since many of these patients develop uric acid kidney stones.

    Normal Results


    Normal values range from 250 to 750 milligrams per 24 hours.
    Note: Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.

    What Abnormal Results Mean


    Higher than normal uric acid levels in the urine may be due to:
    • Cancers that have spread (metastasized)
    • Disorders that affect the bone marrow or certain white blood cells
    • High-purine diet
    • Gout
    • Rhabdomyolysis
    • Lesch-Nyhan syndrome
    • Fanconi syndrome
    Lower than normal uric acid levels in the urine may be due to:
    References

    McPherson RA, Pincus MR. Henry's Clinical Diagnosis and Management by Laboratory Methods. 21st ed. St. Louis, Mo: WB Saunders; 2006.
    Bazari H. Approach to the patient with renal disease. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 115.
    Update Date: 8/10/2009

    Updated by: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

    Uric acid - urine: MedlinePlus Medical Encyclopedia
     
  3. Nzowa Godat

    Nzowa Godat JF-Expert Member

    #3
    Sep 26, 2011
    Joined: Jun 15, 2011
    Messages: 2,534
    Likes Received: 87
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    Where you are! We are pleased to get informed of this medical literacy
     
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