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IST MEDICAL SCHEME CLINIC
PO Box 2651
Dar es Salaam
Tanzania
Tel : +255-22-2601307/8
Fax : +255-222-2600127
Mobile : 0754-783393
E-mail : istclinic@istclinic.com
Date 5/5/2010
Dengue Fever Alert
To our customers,PO Box 2651
Dar es Salaam
Tanzania
Tel : +255-22-2601307/8
Fax : +255-222-2600127
Mobile : 0754-783393
E-mail : istclinic@istclinic.com
Date 5/5/2010
Dengue Fever Alert
In the last weeks several patients ( up to about 20 ) have been diagnosed with possible Dengue Fever, most likely from mosquitos (Aedes Aegypti) that bite also during the day, In Dar es Salaam and Zanzibar.
We are still waiting for confirmation of virological tests (from South Africa)from some of our patients .
In order to protect yourself we advise to use mosquito repellent with DEET and use mosquitonets treated with insecticide.
Information about Dengue Fever signs and symptoms follows below:
Signs and symptoms
The disease manifests as a sudden onset of severe headache, muscle and joint pains (myalgias and arthralgiassevere pain that gives it the nickname break-bone fever or bonecrusher disease), fever, and rash.[8] The dengue rash is characteristically bright red petechiae and usually appears first on the lower limbs and the chest; in some patients, it spreads to cover most of the body.
There may also be gastritis with some combination of associated abdominal pain, nausea, vomiting, or diarrhea.
Some cases develop much milder symptoms which can be misdiagnosed as influenza or other viral infection when no rash is present. Thus travelers from tropical areas may pass on dengue inadvertently, having not been properly diagnosed at the height of their illness.
Patients with dengue can pass on the infection only through mosquitoes or blood products and only while they are still febrile. The classic dengue fever lasts about two to seven days, with a smaller peak of fever at the trailing end of the disease (the so-called "biphasic pattern"). Clinically, the platelet count will drop until the patient's temperature is normal.
Cases of DHF also show higher fever, variable hemorrhagic phenomena, thrombocytopenia, and hemoconcentration. A small proportion of cases lead to dengue shock syndrome (DSS) which has a high mortality rate.Belia Klaassen, MD Ype Smit, MD.
Dengue fever is caused by Dengue virus (DENV), a mosquito-borne flavivirus. DENV is an ssRNA positive-strand virus of the family Flaviviridae; genus Flavivirus. There are four serotypes of DENV. The virus has a genome of about 11000 bases that codes for three structural proteins, C, prM, E; seven nonstructural proteins, NS1, NS2a, NS2b,NS3, NS4a, NS4b, NS5; and short non-coding regions on both the 5' and 3' ends.[9] The potential factors causing hemorrhagic fever are varied. The most suspected factors are The diagnosis of dengue is usually made clinically.
The classic picture is high fever with no localising source of infection, a petechial rash with thrombocytopenia and relative leukopenia - low platelet and white blood cell count. Care has to be taken as diagnosis of DHF can mask end stage liver disease and vice versa.
1. Fever, bladder problem, constant headaches, eye pain, severe dizziness and loss of appetite.
2. Hemorrhagic tendency (positive tourniquet test, spontaneous bruising, bleeding from mucosa, gingiva, injection sites, etc.; vomiting blood, or bloody diarrhea)
3. Thrombocytopenia (<100,000 platelets per mm³ or estimated as less than 3 platelets per high power field)
4. Evidence of plasma leakage (hematocrit more than 20% higher than expected, or drop in hematocrit of 20% or more from baseline following IV fluid, pleural effusion, ascites, hypoproteinemia)
5. Encephalitic occurrences. Dengue shock syndrome is defined as dengue hemorrhagic fever plus: Weak rapid pulse,Narrow pulse pressure (less than 20 mm Hg)
Cold, clammy skin and restlessness.
Dependable, immediate diagnosis of dengue can be performed in rural areas by the use of Rapid Diagnostic Test kits, which also differentiate between primary and secondary dengue infections.[10] Serology and polymerase chain reaction (PCR) studies are available to confirm the diagnosis of dengue if clinically indicated. Dengue can be a life threatening fever.
Comment IST clinic:
So far all cases seen at IST clinic were mild , some patients needed iv fluids. 2 patients were evacuated to Nairobi but recovered well. If you develop these symptoms please come to check your blood. Dont take aspirin, ibuprofen or diclofenac as this medicin can cause internal bleeding. Paracetamol can be used.
Dr Belia Klaassen, May 5, 2010