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HIV Vaccine...Interesting comment!

Discussion in 'International Forum' started by Ab-Titchaz, Oct 21, 2009.

  1. Ab-Titchaz

    Ab-Titchaz Content Manager Staff Member

    #1
    Oct 21, 2009
    Joined: Jan 30, 2008
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    Wakuu,

    Juzi juzi niliwasilisha thread ilioongelea kuhusu the discovery
    of an AIDS vaccine which had been tried in Thailand. Now that
    the dust has died down kuna comment moja iliotolewa na the
    military doctor from the US kua the vaccine would not work in
    Africa (read Africans). This guy does not say why and this leaves
    more questions than answers if not suspicion. Soma zaidi...

    HIV vaccine trial was significant

    [​IMG]

    The search for an HIV vaccine has proved frustrating

    By Matt McGrath
    BBC News science and environment reporter


    A review of a trial of a HIV vaccine in Thailand has concluded that it does show real signs of a protective effect.
    Scientists announced last month that a combination of vaccines gave a 31% level of protection in trials among 16,000 heterosexuals aged 18-30.
    Doubts had been raised about whether the finding was significant.

    But new data published at a conference in Paris indicates that, while small scale, the findings are robust and statistically significant.

    However, the scientists say they do not understand what is causing the effect, and it seems to offer less protection to those most at risk.

    Despite these drawbacks, Colonel Nelson Michael from the US military HIV research program it is still a small step in the right direction.

    He said: "It's important that people understand that this is a scientific advance, a scientific breakthrough.

    "It is not a public health breakthrough; there is not a vaccine that is around the corner.

    "We now, after 26 years of trying, believe that we can go down that road with confidence that we will be able to develop a vaccine that is globally effective."

    Doubts raised

    Despite their initial joy when the first results from the Thai trial were announced, many scientists were concerned that the protective effect was very small.

    Among the 8,000 of so who got the vaccine, 51 became infected with the virus.

    Among those who received a placebo, 74 got the infection.

    However, the trials sponsors, the US military and the Thai government said the 31.2% protective effect was statistically significant and real.

    As more data slowly emerged some scientists began to have doubts about how robust this effect really was.

    When those who had not taken all their vaccines were excluded from the trial the numbers lost their statistical power.

    Many experts were concerned that the data had not been subject to a rigorous examination by other scientists.

    Many questions

    Now that review has taken place. And it indicates that the original findings still stand - but there are more questions than answers.

    The scientists based their conclusions on an analysis of the entire population in the study, excluding just seven people who were found to be infected on the first day of the trial.

    The researchers say this is the most robust way of looking at the study.
    They also published details of two other analyses of the trial, which excluded people who had not taken all their medication.

    Both of these showed effects that were not statistically significant.
    Among the scientists at this meeting there was a real sense of excitement about the findings.

    Dr Nicola Frahm, associate laboratory director for the HIV Vaccines trials network in Seatlle, Washington, said: "Oh my God, it's amazing.

    "There is hope, there is a vaccine that prevented acquisition, the signal is very weak but this is the first time to show any effect on acquisition at all, so for the HIV community it's an amazing day.

    "The real question is to how biologically significant is this?
    "The significance that has been established in this trial is that there is a 5% chance that this is a fluke.

    "So we are 95% certain that what we are seeing is real and not down to pure chance. And that's great."

    No use in Africa

    The researchers point out that this vaccine would not work in Africa where the rates of HIV infection are the highest.

    They say that a commercial product is still many years away and caution that prevention and education are the best protection against the infection in the medium term.

    Colonel Jerome Kim is HIV vaccines product manager for the US Army.
    He said: "We had something that protected a third of the people exposed to the virus in Thailand.

    "It is not a globally effective vaccine; it can not be used outside of Thailand.

    "Until we answer those other scientific questions the idea of using this vaccine in other parts of the world or testing it, is science rather than public health."

    Deborah Jack, chief executive of NAT (National Aids Trust), said: "The Thai trial is a milestone in the search for a vaccine against HIV.
    "These results are an incredible opportunity for scientists to discover new clues about HIV and learn how a HIV vaccine could work in practice."

     
  2. eRRy

    eRRy JF-Expert Member

    #2
    Oct 21, 2009
    Joined: Jun 12, 2009
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    hawa nao? labda dawa haishiki kwenye rangi nyeusi! Mh! wanatubania tu!
     
  3. Ab-Titchaz

    Ab-Titchaz Content Manager Staff Member

    #3
    Oct 21, 2009
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    That was my point exactly. Tutaanza kusikia eti kuna dawa zinatibu
    wazungu pekee na sio waafrika ngozi ngumu.

    Mungu aturehemu tusifike huko.
     
  4. Lekanjobe Kubinika

    Lekanjobe Kubinika JF-Expert Member

    #4
    Oct 21, 2009
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    Thanx. Inawezekana kuwa anaongelea genetical variation towards the vaccine response. Ingawa hajasema wazi, amesema hatakuwa na jibu kamili mpaka wapate majibu ya maswali ya kisayansi wanayojiuliza. Majibu wanayo kwa watu wa Thailand kwa sababu wamefanyia utafiti huko kwa watu ambao tunatofautiana genetically. Mimi sina ugomvi nao kisayansi, waache wapate nafasi ya kutest Afrika, huenda waafrika tukawa na compliance kubwa zaidi kwa vaccine hiyo kuliko hata ilivyoonekana kwa wazungu. Tusihamasike haraka, alisema kama mwanasayansi mwanajeshi, hajazoea kulembesha maneno kama tunavyotaka kusikia.

    Leka
     
  5. m

    mchajikobe JF-Expert Member

    #5
    Oct 21, 2009
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    Tehe tehe tehe,hizi drama nyingine bwana yani hatatukisoma vipi hawa wazungu wanazidi kutujingisha (kutufanya wajinga)tuu,their aim is to hypnotise us,wasituletee wehu wao hapa,mbona madini hawasemi hayawafai wazungu?daily wanakuja kuzoa tuu!!!
     
  6. Ab-Titchaz

    Ab-Titchaz Content Manager Staff Member

    #6
    Oct 21, 2009
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    Wala hujakosea kwenye hilo swala la madini.
     
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