Discussion in 'JF Doctor' started by suregirl, Sep 4, 2012.
Nahitaji kuja nini madhara ya dawa aina ya flagil ? :baby:
Side Effects of Flagyl - for the Consumer
Applies to: tablets
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Flagyl:
Appetite loss; constipation; diarrhea; dizziness; headache; metallic taste; nausea; stomach upset; vomiting.
Seek medical attention right away if any of these SEVERE side effects occur when using Flagyl:Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or
tongue); bloody stools; decreased coordination; increased or decreased urination; numbness, tingling, or burning of the arms, hands, legs, or feet; red, swollen, blistered, or peeling skin; seizures; severe diarrhea; severe or persistent dizziness or headache; sore throat, chills, or fever; speech problems; stiff neck; stomach pain or cramps; vaginal itching, odor, or discharge; vision loss or other vision changes; white patches in the mouth.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
Side Effects by Body System - for Healthcare Professionals
Applies to: compounding powder; intravenous powder for injection; intravenous solution; oral capsule; oral tablet; oral tablet, extended release
The most serious side effects reported with metronidazole have included convulsive seizures, encephalopathy, aseptic meningitis, optic and peripheral neuropathy (primarily characterized by numbness or paresthesia of an extremity). Persistent peripheral neuropathy has been reported with prolonged oral administration of metronidazole.
Nervous system side effects have included encephalopathy, aseptic meningitis, optic neuropathy, peripheral neuropathy, convulsive seizures, headache, dizziness, vertigo, syncope, incoordination, ataxia, confusion, dysarthria, weakness, and insomnia. Disorientation, agitation, hallucinations, and reversible abnormalities in the cerebellar dentate nuclei have been reported.
A rare but serious adverse effect of metronidazole is peripheral neuropathy which is thought to be related to dose and duration of therapy. Most cases occur after doses of 1000 to 2400 mg per day for at least 30 days, or a total dose of 50 grams. Neuropathy is generally
located in the lower extremities and presents with numbness, tingling, and paresthesias. Patients should be advised to discontinue metronidazole if they experience these effects. Neuropathy may be persistent despite discontinuation of metronidazole. Seizures associated with metronidazole are rare, but do occur.
Several cases of MRI abnormalities of the dentate nuclei associated with symptoms of ataxia and dysarthria have been reported. The symptoms and dentate nuclei lesions resolved several weeks after discontinuation of metronidazole. These symptoms and metronidazole-induced lesions in the brain stem and cerebellar nuclei have also been described in rat studies.
Furry tongue, glossitis, and stomatitis may be associated with sudden overgrowth of Candida.
Although metronidazole has been used to treat pseudomembranous colitis, it has rarely also been implicated as a causative agent. These rare cases have been successfully treated with vancomycin.
Gastrointestinal side effects have been common and have included nausea (up to 12%), anorexia, dry mouth, a strange/unpleasant
metallic taste, diarrhea, vomiting, abdominal discomfort, epigastric distress, abdominal cramping, constipation, proctitis, coating of the tongue (furry tongue), glossitis, and stomatitis. A modification of the taste of alcoholic beverages has been reported. Rarely, pseudomembranous colitis and pancreatitis have been reported.
Hypersensitivity side effects have included urticaria, erythematous rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, flushing, nasal congestion, dryness of the mouth (or vagina or vulva), and fever. A serum sickness-like reaction has been reported. Fixed
drug eruptions have been reported and cross-sensitivity to other nitroimidazole derivatives has been demonstrated.
Metronidazole has rarely been associated with a serum sickness-like reaction which presents as arthralgias, malaise, fever, chills, pruritus, and rash.
Other side effects have included fever, instances of darkened urine, and overgrowth of Candida. Metronidazole may produce a disulfiram-like reaction (abdominal distress, nausea, vomiting, flushing, or headache) when taken concurrently with ethanol.
Instances of darkened urine have been investigated. The pigment responsible has not been positively identified; however, it is most likely a metabolite of metronidazole and appears to have no clinical significance.
A disulfiram-like reaction has been reported in some patients drinking ethanol while taking metronidazole. Patients have experienced abdominal distress, vomiting, flushing, nausea, headache, and hypotension. Patients should be advised to refrain from all forms of ethanol while taking metronidazole and for at least 72 hours after the last dose.
Hematologic side effects have included reversible neutropenia (leukopenia) and reversible thrombocytopenia (rare).
Genitourinary side effects have included dysuria, cystitis, polyuria, incontinence, vaginal candidiasis, vaginal itching, darkened urine, dyspareunia, and a sense of pelvic pressure.
Cardiovascular side effects have included flattening of the T-wave in electrocardiographic tracings.
Dermatologic side effects have included erythematous rash and pruritus.
Local side effects have included thrombophlebitis following intravenous infusion.
Thrombophlebitis can be minimized or avoided by avoiding prolonged use of indwelling intravenous catheters.
Psychiatric side effects have included irritability, depression, and decreased libido.
Musculoskeletal side effects have included fleeting joint pains sometimes resembling "serum sickness".
Oncologic side effects have included breast and colon cancer in Crohn's disease patients treated with high doses of metronidazole for extended periods of time..@Mamaafacebook
Thank you MziziMkavu
Zinatoa mimba kama itakuwa changa
Wewe sasa ndo umeharibu,
Hajaharibu pia n.side effect