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Finally - Cure for HIV

Discussion in 'Habari na Hoja mchanganyiko' started by Nyambala, Dec 15, 2010.

  1. Nyambala

    Nyambala JF-Expert Member

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    Evidence for the cure of HIV infection by CCR5[​IMG]32/[​IMG]32 stem cell transplantation

    Kristina Allers1,*, Gero Hütter2, Jörg Hofmann3, Christoph Loddenkemper4, Kathrin Rieger2, Eckhard Thiel2 and Thomas Schneider1

    1 Department of Gastroenterology, Infectious Diseases, and Rheumatology, Medical Clinic I, Campus Benjamin Franklin, Charite - University Medicine Berlin, Germany; 2 Department of Hematology, Oncology, and Transfusion Medicine, Medical Clinic III, Campus Benjamin Franklin, Charite - University Medicine Berlin, Germany; 3 Institute of Medical Virology, Helmut-Ruska-Haus, Campus Mitte, Charite - University Medicine Berlin, Germany; 4 Institute of Pathology/Research Center ImmunoSciences (RCIS), Campus Benjamin Franklin, Charite - University Medicine Berlin, Germany
    * Corresponding author; email: kristina.allers@charite.de


    [SIZE=+1]Abstract[/SIZE] HIV entry into CD4+ cells requires interaction with a cellular receptor, generally either CCR5 or CXCR4. We have previously reported the case of an HIV-infected patient in whom viral replication remained absent despite discontinuation of antiretroviral therapy after transplantation with CCR5[​IMG]32/[​IMG]32 stem cells.

    However, it was expected that the long-lived viral reservoir would lead to HIV rebound and disease progression during the process of immune reconstitution. In the present study, we demonstrate successful reconstitution of CD4+ T cells at the systemic level as well as in the gut mucosal immune system following CCR5[​IMG]32/[​IMG]32 stem cell transplantation, while the patient remains without any sign of HIV infection.

    This was observed although recovered CD4+ T cells contain a high proportion of activated memory CD4+ T cells, i.e. the preferential targets of HIV, and are susceptible to productive infection with CXCR4-tropic HIV.

    Furthermore, during the process of immune reconstitution, we found evidence for the replacement of long-lived host tissue cells with donor-derived cells indicating that the size of the viral reservoir has been reduced over time. In conclusion, our results strongly suggest that cure of HIV has been achieved in this patient.

    Source: Hapa
     
  2. Nyambala

    Nyambala JF-Expert Member

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    Researchers report possible HIV infection cure; others cite dangers


    CNN) -- Researchers in Germany are reporting that they may have cured a man of HIV infection. If true, that would represent a scientific advance, but not necessarily a treatment advance, said researchers familiar with the work.

    In the study, published last week online in the journal Blood, researchers at Charite-University Medicine Berlin treated an HIV-infected man who also had acute myeloid leukemia -- a cancer of the immune system -- by wiping out his own immune system with high-dose chemotherapy and radiation and giving him a stem-cell transplant. Stem cells are immature cells that can mature into blood cells.
    At the time of the transplant, which occurred in February 2007, he stopped taking anti-HIV medications.

    Thirteen months later, after a relapse of the leukemia, he underwent a second round of treatment followed by another stem-cell transplant from the same donor.

    The donor's stem cells contained a rare, inherited gene mutation that made them naturally resistant to infection with HIV, according to the authors, led by Kristina Allers, who hypothesized that HIV would nevertheless rebound over time. But that has not happened.
    After three-and-a-half years off of anti-HIV drugs, the patient shows no sign of either leukemia or HIV replication and his immune system has been restored to normal health, the researchers reported, concluding, "our results strongly suggest that cure of HIV has been achieved in this patient."

    But AIDS researchers predicted the report will have little impact on practice.
    "This probably is a cure, but it comes at a bit of a price," said Dr. Michael Saag, professor of medicine and director of the University of Alabama at Birmingham AIDS Center.

    "For him to receive the donor cells, his body had to have all of his immune system wiped out" and then receive a bone marrow transplant, Saag noted. "The Catch-22 here is that the best candidates for a cure, ideally, are people who are healthy" and don't have leukemia.
    The treatment associated with wiping out the immune system "is very hazardous," he said in a telephone interview.

    "Even if somebody doesn't die from a transplant, there are complications that make it very unpleasant for people to live with," he said, citing graft-versus-host disease, where the infused donor cells attack the body. In a number of cases, the transplant proves fatal.

    The study is a proof of the concept "that our understanding of HIV biology is correct, and that if you eliminate -- not just in theory but in practice -- all of the cells in the body that are producing HIV and replace them with uninfected cells, you have a cure," Saag said.

    But remaining infected with HIV is not always associated with the same grim outcome that was the norm prior to the mid-1990s, when more effective anti-HIV drugs were developed, he said.

    "We can keep people alive for a normal life span," he said. "That means a 25-year-old diagnosed today with HIV has a reasonably good chance of living to 80, 85, 90."
    Further limiting the treatment's potential appeal is the fact that it could cost hundreds of thousands of dollars for each patient who gets it, he said.

    "It's not going to be applicable unless they develop leukemia or lymphoma and need a bone-marrow transplant,"Saag said.
    Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, called it impractical. "It's hard enough to get a good compatible match for a transplant like this," he said in a statement. "But you also have to find (a) compatible donor that has this genetic defect, and this defect is only found in 1% of the Caucasian population and 0% of the black population.

    This is very rare."
    But HIV itself is not. According to the World Health Organization, 33.4 million people worldwide have the virus that causes AIDS.
     
  3. Kimbweka

    Kimbweka JF-Expert Member

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    taratibu mkuu huu wimbo ni wa siku nyingi lakini haujawahi kuwa na mafanikio
    Sijui kwa haya kama ni ya kweli:A S-alert1:
     
  4. Nyambala

    Nyambala JF-Expert Member

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    Nadhani hata hizo articles hujazisoma!!
     
  5. T

    Taso JF-Expert Member

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    kwa hiyo hakuna tofauti na uponyaji wa Mheshimiwa Mama Rwakatare na Mchungaji Zakaria Kakobe in the sense that anakuja na mgonjwa wake mmoja kwa kila ugonjwa, anamtibu mbele yetu lakini hakuna mgonjwa wa pili anaeponywa kwa ugonjwa ule ule na dawa ile ile.

    Kwenye sayansi ya utibabu huwezi kutibu binadamu mmoja halafu tukaambiwa "finally tiba imepatikana."

    Bado ni utafiti, abiria endelea kushikilia suruali.
     
  6. Nyambala

    Nyambala JF-Expert Member

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    If you have been following up on this research utakubaliana nami kwamba nothng like this has ever been done before and therefore habari hii inadeserve optimisim as to the direction of huo utafiti! mwishop kabisa "finally tiba imepatikana." ni tafsiri yako binafsi!
     
  7. Kimbweka

    Kimbweka JF-Expert Member

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    Nimezisoma kwa undani kabisa:A S-alert1:
     
  8. Kimbweka

    Kimbweka JF-Expert Member

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    Kabisa Mkuu Tena Piga na kufuli kabisa
     
  9. Nyambala

    Nyambala JF-Expert Member

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    That is good then! Tukumbuke pia historia ya tiba ya TB wasn't that simple lakini leo hii kuna chanjo na pia in just two weeks with a pill a day inakuwa imetibika.
     
  10. M

    Mike 1234 JF-Expert Member

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    Habari njema naamini ipo siku hili gonjwa litakuwa historia
     
  11. Kigogo

    Kigogo JF-Expert Member

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    mnataka watu watupe mavidonge waanza kulana kavu kavu mwanzo mwisho
     
  12. M

    Malunde JF-Expert Member

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    This is a step ahead
     
  13. T

    Taso JF-Expert Member

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    Kumbe tunaongelea optimism ya research tu, basi usiseme "hatimae tiba ya ukimwi" as if imepatikana

    si kweli
     
  14. Nyambala

    Nyambala JF-Expert Member

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    Unajua tatizo ni kwamba una hamu mno ya kuniwekea maneno mdomoni wakati articles zinajieleza zenyewe. You have it in your mind kwamba I am trying to advocate something non-existing. The fact ni kwamba I am just relaying something i find interesting done by others like never before.
     
  15. Zipuwawa

    Zipuwawa JF-Expert Member

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    Bora ipatikane tumechoka kulamba sukari kwenye mifuko
     
  16. Nyambala

    Nyambala JF-Expert Member

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    Huwa nashangazwa sana na huu mtizamo kuhusu HIV/ AIDS it is something strange and fun na inaielezea ni namna gani jamii yetu ilivyo.
     
  17. Nyambala

    Nyambala JF-Expert Member

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    Na vp kuhusu uzazi wa mpango?
     
  18. Zipuwawa

    Zipuwawa JF-Expert Member

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    Uzazi wa mpango utaeleweka tu
     
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