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diuretics causes gout

Discussion in 'JF Doctor' started by msoga, Mar 29, 2012.

  1. m

    msoga New Member

    Mar 29, 2012
    Joined: Mar 28, 2012
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    causes this by increasing the reabsorption of urate and decreasing the excreation of it
    by using the lactate-urate transporter mechanism
    and this is initiated indirect by sodium-hydrogen transporter mechanism which cause alkaline condition in the cell
    compered by the lumen in the proximol convuluted tube hense stimulate the hydroxyl shifting mechanism
  2. vicent tibaijuka

    vicent tibaijuka JF-Expert Member

    Mar 29, 2012
    Joined: Mar 22, 2012
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    when you talk abt diuretics you should know the groups and its mechanism! don't generalize! if you understand the physiology of kidney, u'll find out that the reabsorptionof minerals & water differ in part nephron (I don't have to tell u go and read). In that case we have three types diuretics with quite different mechanisms. eg. 1.Thiazides (bandroflumethiazide,hydrochlorothiazide) 2. Loop diuretics (bumentanide,furosemide, torsemide and ethacrynic acid9. 3.Potassium-sparing diuretics (amiloride,spironolactone etc). if you gonna read much u gonna find that its thiazides and loop of henle diuretics which may cause exacerbation of gout.