Breakthrough in Discovery of An AIDS Vaccine

[Ab-Titchaz]

Trial HIV vaccine cuts infection ​

An experimental HIV vaccine has for the first time cut the risk of infection, researchers say. The vaccine - a combination of two earlier experimental vaccines - was given to 16,000 people in Thailand, in the largest ever such vaccine trial.

Researchers found that it reduced by nearly a third the risk of contracting HIV, the virus that leads to Aids. It has been hailed as a significant, scientific breakthrough, but a global vaccine is still some way off.

The study was carried out by the US army and the Thai government over seven years on volunteers - all HIV-negative men and women aged between 18 and 30 - in some of Thailand's most badly-affected regions.

The vaccine was a combination of two older vaccines that on their own had not cut infection rates.

Half of the volunteers were given the vaccine, while the other half were given a placebo - and all were given counselling on HIV/Aids prevention. Participants were tested for HIV infection every six months for three years.

The results found that the chances of catching HIV were 31.2% less for those who had taken the vaccine - with 74 people who did not get the vaccine infected and 51 of the vaccinated group infected.

'Encouraging'

"This result is tantalisingly encouraging. The numbers are small and the difference may have been due to chance, but this finding is the first positive news in the Aids vaccine field for a decade," said Dr Richard Horton, editor of the Lancet medical journal.

"We should be cautious, but hopeful. The discovery needs urgent replication and investigation."

Dr Anthony Fauci, director of the US National Institute of Allergy and Infectious Diseases said: "For the first time, an investigational HIV vaccine has demonstrated some ability to prevent HIV infection among vaccinated individuals.

"Additional research is needed to better understand how this vaccine regimen reduced the risk of HIV infection, but this is certainly an encouraging advance for the HIV vaccine field."

The findings were hailed by the World Health Organization (WHO) and the Joint United Nations Programme on HIV/Aids (UN/Aids).

They said while the results were "characterised as modestly protective... [they] have instilled new hope in the HIV vaccine research field".

Some 33 million people around the world have HIV.

http://news.bbc.co.uk/2/hi/health/8272113.stm

 

[Mbu]

The study was carried out by the US army and the Thai government over seven years on volunteers - all HIV-negative men and women aged between 18 and 30 - in some of Thailand's most badly-affected regions.
The vaccine was a combination of two older vaccines that on their own had not cut infection rates.

Half of the volunteers were given the vaccine, while the other half were given a placebo - and all were given counselling on HIV/Aids prevention. Participants were tested for HIV infection every six months for three years.

The results found that the chances of catching HIV were 31.2% less for those who had taken the vaccine - with 74 people who did not get the vaccine infected and 51 of the vaccinated group infected.

....hureeeeeeeee! ... lakini hilo la Volunteers (walalahoi) ndilo lililoniacha hoi... wali volunteer (bila ushawishi wa $ chache) wenyewe kufanywa Guinea pigs kwa kirusi cha UKIMWI?

Inasikitisha sana.

 

[Masanilo]

"We should be cautious, but hopeful. The discovery needs urgent replication and investigation."

This trial needs to be replicated elsewhere.......dropouts na outliers huwa wanaondolewa kwenye analysis kusuits interest ya researchers.....HIV vaccine is still far away....I will have a thoroughly look of that lancet paper

My worry is ...HIV virus has a moving target. The virus replicates rapidly and has a high mutation rate creating highly diverse 'quasispecies'. These quasispecies are fertile substrates for darwinian selective pressures favoring the best-adapted, most 'fit' genetic variants. Efforts to develop effective treatments and vaccines must overcome the complex evolutionary dynamics in HIV-infected individuals and within affected populations. Replication rate is so high kutarget a particular conserved region is a nightmare wazee tuendee kujiepusha na ngono.....Umwamba wa science bado....!

 

[Steve Dii]

Tusife moyo. Ipo siku watafanikiwa kupata kinga. Walete huku bongo haya majaribio.

 

[Masanilo]

Tusife moyo. Ipo siku watafanikiwa kupata kinga. Walete huku bongo haya majaribio.

Hahahaha kaka utakuwa tayari kuwa exposed hahahah acha utani, vaccine trial hufanyika kwenye idea situation wakija kwenye real world watakimbia na majibu yao! soma hapo juu nilichoandika!

 

[Masanja]

Duh..wafrika bana..bora tukajilimie mihogo....tuendelee kwenda madhabahuni kila jumapili..kuomba Mungu awasaidie wazungu wavumbue dawa ya Ukimwi watulutee....

 

[Masanilo]

Duh..wafrika bana..bora tukajilimie mihogo....tuendelee kwenda madhabahuni kila jumapili..kuomba Mungu awasaidie wazungu wavumbue dawa ya Ukimwi watulutee....

Home Boy Vipi Bwana.....tuendelee kubadili tabia, zile hatarishi kama mitala na kuwa na partners lukuki tuache.

 

[Asprin]

Home Boy Vipi Bwana.....tuendelee kubadili tabia, zile hatarishi kama mitala na kuwa na partners lukuki tuache.

Thanks man. I like your avatar! Kale kakitu kangekuwa na vigongomelo namna hiyo labda ukimwi utasepa. Hahahaha!!

 

[Masanilo]

Thanks man. I like your avatar! Kale kakitu kangekuwa na vigongomelo namna hiyo labda ukimwi utasepa. Hahahaha!!

Teh teh teh kwa kweli.....! Unajua UKIMWI ni janga kubwa, hakuna familia isiyojua adha yake...kaka, dada, mjomba, marafiki, wazazi, jamaa lazima ukijiangalia kuna pigo sehemu.

 

[Ab-Titchaz]

Duh..wafrika bana..bora tukajilimie mihogo....tuendelee kwenda madhabahuni kila jumapili..kuomba Mungu awasaidie wazungu wavumbue dawa ya Ukimwi watulutee....

Masanja,

Huyo Mungu naye mbona asitusaidie sisi waafrika tuvumbue hii dawa
kisha tuwapo hao 'wazungu'?...

There is hope!

 

[Steve Dii]

Masanja,

Huyo Mungu naye mbona asitusaidie sisi waafrika tuvumbue hii dawa
kisha tuwapo hao 'wazungu'?...

There is hope!

Wewe naona unataka NN aje kukujibu tu.... lol

 

[Ab-Titchaz]

This trial needs to be replicated elsewhere.......dropouts na outliers huwa wanaondolewa kwenye analysis kusuits interest ya researchers.....HIV vaccine is still far away....I will have a thoroughly look of that lancet paper

My worry is ...HIV virus has a moving target. The virus replicates rapidly and has a high mutation rate creating highly diverse 'quasispecies'. These quasispecies are fertile substrates for darwinian selective pressures favoring the best-adapted, most 'fit' genetic variants. Efforts to develop effective treatments and vaccines must overcome the complex evolutionary dynamics in HIV-infected individuals and within affected populations. Replication rate is so high kutarget a particular conserved region is a nightmare wazee tuendee kujiepusha na ngono.....Umwamba wa science bado....!

Nice observation.

As a note however, kumbuka kua in these mutating things target ya
scientists ni ku-stop replication by 'arresting' the DNA synthesis. Thats
the basis of most of these kinds of diseases ndo maana unasikia
madaktari wakisema "We can treat it but we cannot cure it."

Mimi naamini hii vaccine itapatikana tu kisha watu wataendeleza tabia
za ngono maana kwa sasa kitumbua kimeingia mchanga na watu
wamepunguza 'umegaji'.

Good day.

 

[Ab-Titchaz]

Wewe naona unataka NN aje kukujibu tu.... lol

Duh!..nilikua nimesahau...Ndivyo tulivyo sio?...

 

[Ab-Titchaz]

....hureeeeeeeee! ... lakini hilo la Volunteers (walalahoi) ndilo lililoniacha hoi... wali volunteer (bila ushawishi wa $ chache) wenyewe kufanywa Guinea pigs kwa kirusi cha UKIMWI?

Inasikitisha sana.

Mbu,

Ku-volunteer ndio hali yake hio. Kisha hawa walalahoi si unajua tena,
bora fweza ipo watakubali mtindo mmoja maana life is hard for them
anyway. Kuna kauli nishasikia walevi wakisema mangweni, eti "If it
doesn't kill me then something else will"...kufa gari kufa dreva kwa
ufupi!

 

[NGULI]

I am loving the arguement

 

[Asprin]

Masanja,

Huyo Mungu naye mbona asitusaidie sisi waafrika tuvumbue hii dawa
kisha tuwapo hao 'wazungu'?...

There is hope!

Sisi zetu ni kuomba, wenzetu wako bize kwenye maabara.

 

[Hofstede]

Trial HIV vaccine cuts infection ​

It has been hailed as a significant, scientific breakthrough, but a global vaccine is still some way off.

Hii line ndiyo muhimu kuliko zote. Ni lazima tuendelee na tahadhari kwani ukimwi bado unaenea kwa kasi sana na mpaka chanjo ifike africa, extra 30mill watakuwa tayari wameambukizwa. Sasa angalia mtu usije jikuta ni miongoni mwao

 

[Kaizer]

Hivi hawa waganga wetu wa jadi wenye mabango kila mahali wanatibu ukimwi mbona wasipeleke machapisho yao huko 'duniani' huenda wana dawa tayari ila ndo ivo hawajapata 'exposure'?

 

[Nono]

....hureeeeeeeee! ... lakini hilo la Volunteers (walalahoi) ndilo lililoniacha hoi... wali volunteer (bila ushawishi wa $ chache) wenyewe kufanywa Guinea pigs kwa kirusi cha UKIMWI?
Inasikitisha sana.

Mbu, unakosea kidogo. Sio kwamba watu walivoluntia kuambukizwa, ni kwamba, unakwenda sehemu unayofahamu kuwa maambukizi ni makubwa, unawaeleza watu juu ya utafiti wako na wanakua huru kushiriki au kutoshiriki. Wale wanaokubali, wanagawanywa katika makundi mawili bila wao kufahamu. Kundi moja linapewa chanjo inayojaribiwa na jingine linapewa "kanyaboya", halafu unawaacha waendelee na maisha yao ya kila siku (wapo watakaoduu bila kinga na watakaotumia kinga kwa utashi wao wenyewe), siku ya mwisho unakuja kuwapima kupata idadi ya walioambukizwa katika kila kundi.

 

[Yo Yo]

Aaameeni......